Evidence for long-term association of virion-delivered HBV core protein with cccDNA independently of viral protein production

Background & Aims: HBV persists in the nucleus of infected hepatocytes as a covalently closed circular DNA (cccDNA) episome that constitutes the template for viral RNA and protein synthesis.Both HBx and HBc (core) viral proteins associate with cccDNA but, corvette lanyard while HBx is required for viral transcription, the role of HBc is still u

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